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Tetraphase Pharmaceuticals

Biotech & Life Sciences · Watertown, United States · Founded 2006

Antibiotics to treat multi-drug resistant bacterial infections MoreLess

Tetraphase Pharmaceuticals is dedicated to addressing one of the most critical threats to global health: antibiotic resistance. The company specializes in the development of novel antibiotics aimed at treating infections caused by multidrug-resistant (MDR) bacteria. Utilizing proprietary chemistry technology, Tetraphase is creating multiple tetracycline-based antibiotics that show promise against some of the most challenging MDR bacteria. The company's mission is to make these innovative antibiotics accessible to all patients who need them, thereby potentially changing the course of antibiotic resistance for millions at risk.

Tetraphase operates in the pharmaceutical and biotechnology market, primarily serving healthcare providers, hospitals, and patients who are in dire need of effective treatments against resistant bacterial infections. The business model revolves around research and development (R&D) of new antibiotic drugs, followed by clinical trials, regulatory approvals, and eventual commercialization. Revenue is generated through the sale of these antibiotics, as well as potential out-licensing agreements for their pipeline products.

Keywords: antibiotic resistance, multidrug-resistant bacteria, tetracycline-based antibiotics, proprietary chemistry, healthcare providers, biotechnology, pharmaceutical R&D, clinical trials, regulatory approvals, out-licensing.

Company overview

Tetraphase Pharmaceuticals company information

The essential company record, classifications and operating signals in one place.

Status
Acquired
Founded
2006
Headquarters
Watertown, United States
Employees
13
Open positions
None listed
Dealroom signal
70.8
client focusb2csub industryPharmaceuticalsub industryBioTechnologybusiness modelManufacturingindustryHealthsectorRisk ManagementsectorBiotechnologysectorSpinoutsectorBiotech and PharmasectorDT and LSsectorscience-based

Valuation & funding

Tetraphase Pharmaceuticals funding history

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
ACQUISITIONOther financing Jul 2020 $43M $43M La jolla Pharmaceutical
ACQUISITIONOther financing Mar 2020 $14M $14M Talphera
GRANTOther financing Apr 2017 $4M CARB-X
IPOOther financing Mar 2013 $0 Undisclosed
GROWTH EQUITY VCOther financing Jan 2012 $0 Undisclosed
SERIES COther financing Jun 2010 F-Prime · CMEA Capital · Excel Venture Management · Skyline Ventures
SERIES BOther financing Sep 2009 Skyline Ventures · Flagship Pioneering · Mediphase Venture Partners · F-Prime
SERIES AOther financing Aug 2008 Undisclosed
SERIES AOther financing Nov 2006 Mediphase Venture Partners
SPINOUTOther financing Jan 2006 Harvard University
Showing 10 recorded eventsUnlock the complete deal history →

Financials

Revenue, earnings and profit over time

Reported history and available estimates. Estimated years are marked “E”; sparse fields are left blank rather than inferred.

YearRevenueGrowthEBITDAMargin
2026 $22M 0% −$18M -81.8%
2025 $22M 0% −$18M -81.8%
2024 $22M 0% −$18M -81.8%
2023 $22M 0% −$18M -81.8%
2022 $22M +37.5% −$18M -81.8%
2021 $16M +60% −$18M -112.5%
2020 $10M −$29M -290%
Company filings, research estimates and Dealroom dataOpen the full financial model →

Growth signals

Tetraphase Pharmaceuticals website traffic

Latest recorded traffic for Tetraphase Pharmaceuticals is 240 monthly website visits, up 500% over the last three months. Tetraphase Pharmaceuticals's team declined 48% over the past year.

Latest monthly visits240 3-month web change+500% 1-year team growth-48%
Monthly website visits78 observations · Apr 2016–Nov 2025
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Comparisons

Tetraphase Pharmaceuticals compared with similar companies

Dealroom’s weighted taxonomy model identifies the closest operating peers. Company identity and context stay open; selected comparison metrics preview what is available in the platform.

Showing 8 of the closest matchesCompare every metric →

Talent graph

Tetraphase Pharmaceuticals's talent

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Team profiled 10 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 2 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Investors

15 investors on Tetraphase Pharmaceuticals's cap table

Sourced from Dealroom's funding and investor records. Investor profile links are shown where available.

Seed 1 investor entered at this stage
CARB-X
Series A 4 investors entered at this stage
Mediphase Venture Partners
Skyline Ventures
Flagship Pioneering
F-Prime
Series B+ 2 investors entered at this stage
Excel Venture Management
CMEA Capital
Other known 8 additional known investors
Harvard University
La jolla Pharmaceutical
Talphera
Bay City Capital
CB Health Ventures
Eight Roads Ventures
Fidelity Ventures
US Biomedical Advanced Research and Development Authority

Global footprint

Where Tetraphase Pharmaceuticals has talent and traffic

Workforce by country
1 countries with
team presence
🇺🇸 United States100%
1 country shown

In the news

Latest news about Tetraphase Pharmaceuticals

Recent press, funding announcements, and product moves mentioning Tetraphase Pharmaceuticals — open to read from the original sources.

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Market sentiment

What the market is saying about Tetraphase Pharmaceuticals

An AI-synthesized read of the highest-engagement posts about Tetraphase Pharmaceuticals on X over the past 7 days. We rank by likes & retweets, ignore corporate channels, and surface the themes that broke out from real people.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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