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Profluent

Biotech & Life Sciences · Emeryville, United States · Founded 2022

Generative AI platform designing functional proteins for therapeutics MoreLess

Profluent.bio is a cutting-edge startup that operates at the intersection of artificial intelligence (AI) and biology. The company specializes in creating custom proteins designed for breakthrough medicines, aiming to revolutionize genetic medicine. Profluent.bio serves clients in the pharmaceutical and biotechnology sectors, particularly those focused on developing treatments for genetic diseases.

The market Profluent.bio operates in is the rapidly growing field of gene editing and synthetic biology. This market is driven by the increasing demand for innovative therapies that can address previously untreatable genetic conditions. The company's unique approach leverages AI to optimize protein design, making it more efficient and cost-effective for their partners to achieve commercial success.

Profluent.bio's business model is based on partnerships with pharmaceutical and biotech companies. They provide these partners with bespoke protein solutions that are tailored to specific therapeutic needs. By using AI to decode the "language of life," Profluent.bio can create proteins that go beyond the capabilities of natural or existing patented proteins. This allows their partners to develop more effective and precise treatments.

The company generates revenue through these partnerships, likely involving a combination of upfront fees, milestone payments, and royalties on the successful commercialization of the therapies developed using their proteins.

In summary, Profluent.bio is a pioneering company that uses AI to create custom proteins for genetic medicine, serving pharmaceutical and biotech clients. They operate in the gene editing and synthetic biology market, with a business model focused on partnerships and revenue from collaborative projects.

Keywords: AI, biology, gene editing, synthetic biology, custom proteins, genetic medicine, pharmaceutical, biotech, partnerships, innovation.

Company overview

Profluent company information

The essential company record, classifications and operating signals in one place.

Status
Operational
Founded
2022
Headquarters
Emeryville, United States
Employees
69
Open positions
17
Dealroom signal
94.7
client focusb2btechnologyArtificial IntelligencetechnologyDeep TechtechnologyMachine Learningsub industryBioTechnologybusiness modelManufacturingindustryHealthsectorBiotechnologysectorDrug DevelopmentsectorCore AIsectorPrecision MedicinesectorSynthetic BiologysectorCrisprsectorNovel AI

Valuation & funding

Profluent funding history

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
LATE VCOther financing Nov 2025 $106M $424M Spark Capital · Air Street Capital · Convergent Ventures · Altimeter Capital
EARLY VCOther financing Mar 2024 $35M $140M Insight Partners · Jeff Dean · Air Street Capital · Spark Capital
EARLY VCOther financing Aug 2022 $8M $32M Undisclosed
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Growth signals

Profluent website traffic

Latest recorded traffic for Profluent is 8.2K monthly website visits, down 5.7% over the last three months. Profluent's team grew 46.8% over the past year.

Latest monthly visits8.2K 3-month web change-5.7% 1-year team growth+46.8%
Monthly website visits46 observations · Oct 2022–Jul 2026
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Comparisons

Profluent compared with similar companies

Dealroom’s weighted taxonomy model identifies the closest operating peers. Company identity and context stay open; selected comparison metrics preview what is available in the platform.

Showing 8 of the closest matchesCompare every metric →

Talent graph

Profluent's talent

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Team profiled 12 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 2 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Investors

8 investors on Profluent's cap table

Sourced from Dealroom's funding and investor records. Investor profile links are shown where available.

Series A 4 investors entered at this stage
Series B+ 4 investors entered at this stage
Altimeter Capital
Bezos Expeditions
Convergent Ventures
AIX Ventures

Global footprint

Where Profluent has talent and traffic

Workforce by country
2 countries with
team presence
🇺🇸 United States98.1%
🇫🇷 France1.9%
2 countries shown

In the news

Latest news about Profluent

Recent press, funding announcements, and product moves mentioning Profluent — open to read from the original sources.

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Market sentiment

What the market is saying about Profluent

An AI-synthesized read of the highest-engagement posts about Profluent on X over the past 7 days. We rank by likes & retweets, ignore corporate channels, and surface the themes that broke out from real people.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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