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City Therapeutics

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Innovative RNAi therapeutics company advancing next-gen trigger molecules for transformative disease treatment

United StatesBiotech & Life Sciences
Valuation $500M–1B Latest valuation · 2026
Headcount <100 Current team size
Total funding $100–500M Disclosed equity funding
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About City Therapeutics

City Therapeutics is at the forefront of developing RNA interference (RNAi) therapeutics, focusing on creating next-generation trigger molecules to treat a wide array of diseases. The company operates in the biotechnology sector, targeting prevalent disease indications where RNAi therapeutics have distinct advantages over traditional treatments like small molecules and antibodies. City Therapeutics serves patients who benefit from advanced RNAi-based medicines, aiming to make a significant impact across multiple therapeutic areas. The business model revolves around leveraging proprietary RNAi trigger molecules and tailored targeting ligands to enhance delivery and efficacy, thus expanding the reach of RNAi therapeutics. Revenue is generated through the development and commercialization of these innovative treatments, potentially in collaboration with other biotech firms or through direct market entry. The company is led by pioneering executives and scientists who were instrumental in the creation of the first generation of RNAi therapeutics, ensuring a strong foundation in both scientific expertise and industry leadership. City Therapeutics is committed to harnessing the latest advancements in human genetics to improve and expand the capabilities of RNAi-based medicines. Keywords: RNAi, therapeutics, biotechnology, trigger molecules, disease treatment, targeting ligands, gene silencing, siRNAs, human genetics, biotech innovation.

Source: Dealroom company data

At a glance

Status
Operational
Headquarters
United States
Employees
85
Open positions
5
Dealroom signal
0.0/100
Industry
Health
Sub-industry
BioTechnology
Sector
Biotech & Life Sciences, Biotechnology, Biotech and Pharma, DT and LS
Business model
Manufacturing
Client focus
b2b

Latest news

Press, funding announcements and product moves mentioning City Therapeutics.

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Funding history

2 recorded events

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
SERIES BOther financing Jun 2026 $100M $675M Fidelity Investments · Invus · Rock Springs Capital · ARCH Venture Partners
SERIES AOther financing Oct 2024 $135M $540M Invus · Rock Springs Capital · Slate Path Capital · AN Venture Partners
Showing the latest 2 of 2 recorded eventsBook a demo for the full funding history →

Growth signals

City Therapeutics website traffic

Latest recorded traffic for City Therapeutics is 6.7K monthly website visits, up 103% over the last three months.

Latest monthly visits6.7K 3-month web change+103%
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Similar companies

Closest operating peers by Dealroom taxonomy

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AnvesanaDevelops therapeutics to boost protein expression, addressing rare genetic disorders and complex diseases using an RNA-sequence analysis platform New York City, United States Operational
NGENIESS BiosciencesNGENIESS N-Link Tech offers a protein modification kit utilizing TA4C technology for precise N-terminus fluorescence alteration, intended for pre-sale testing with a mandatory agreement prior to use Tokyo, Japan Operational
PopVaxAn Indian biotech company, develops mRNA vaccines through computational protein design, aiming to save 1 million lives annually Hyderabad, India Operational
Orbital TherapeuticsAims to enhance global health by unleashing the full potential of RNA-based medicines to treat human disease San Francisco, United States Acquired
Normax BiomedNormax focus for 2022 is rapid growth in mRNA Vaccine R&D and manufacturing for sustainable pandemic preparedness Cork, Ireland Operational
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Investors

11 investors on the cap table

From Dealroom's funding and investor records, grouped by the round each investor first entered.

Series A11 investors entered at this stage

Team profiled 4 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 2 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Global footprint

Workforce and web traffic by country
Workforce by country
2 countries with
team presence
🇺🇸 United States98.4%
🇬🇧 United Kingdom1.6%
2 countries shown

Market sentiment

Posts on X, past 7 days

An AI-synthesised read of the highest-engagement posts about City Therapeutics on X, ranked by likes and reposts, corporate channels excluded.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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